SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability

Abstract R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid duplex and a displaced single-stranded DNA loop. Unscheduled or persistent R-loops drive genome instability by creating conflicts with transcription and replication. Up to 75% of the human genome comprises repe...

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Detaylı Bibliyografya
Asıl Yazarlar:	Alessandro Ferrando, Michele Giaquinto, Luisa M. R. Napolitano, Giulia Canarutto, Alessandro Framarini, Alice Gambelli, Pamela Veneziano Broccia, Annie Zappone, Eleonora Petti, Chiara Boncristiani, Andrea Parlante, Silvia Onesti, Silvano Piazza, Roberta Benetti, Stefan Schoeftner
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2026-02-01
Seri Bilgileri:	Nature Communications
Online Erişim:	https://doi.org/10.1038/s41467-026-69479-w
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability

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