SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability

Abstract R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid duplex and a displaced single-stranded DNA loop. Unscheduled or persistent R-loops drive genome instability by creating conflicts with transcription and replication. Up to 75% of the human genome comprises repe...

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書誌詳細

主要な著者:	Alessandro Ferrando, Michele Giaquinto, Luisa M. R. Napolitano, Giulia Canarutto, Alessandro Framarini, Alice Gambelli, Pamela Veneziano Broccia, Annie Zappone, Eleonora Petti, Chiara Boncristiani, Andrea Parlante, Silvia Onesti, Silvano Piazza, Roberta Benetti, Stefan Schoeftner
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-02-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-026-69479-w
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