Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli

Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptide nucleic acids (PNAs), directed against DnaA tran...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Christopher Campion, Godefroid Charbon, Peter E. Nielsen, Anders Løbner-Olesen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2024-04-01
Sarja:	Frontiers in Antibiotics
Aiheet:	novel antibiotics antisense PNA-peptide chromosome replication DnaA initiator protein inhibition of initiation Escherichia coli
Linkit:	https://www.frontiersin.org/articles/10.3389/frabi.2024.1384390/full
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