Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli

Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptide nucleic acids (PNAs), directed against DnaA tran...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Christopher Campion, Godefroid Charbon, Peter E. Nielsen, Anders Løbner-Olesen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2024-04-01
Σειρά:	Frontiers in Antibiotics
Θέματα:	novel antibiotics antisense PNA-peptide chromosome replication DnaA initiator protein inhibition of initiation Escherichia coli
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/frabi.2024.1384390/full
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