Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin

Abstract Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic acid. Sialic acid is a negatively charged monosacch...

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Bibliografische Detailangaben

Hauptverfasser:	Elex S. Harris, Hannah J. McIntire, Marina Mazur, Hinnerk Schulz-Hildebrandt, Hui Min Leung, Guillermo J. Tearney, Stefanie Krick, Steven M. Rowe, Jarrod W. Barnes
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-07-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-024-66510-2
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