Development of an RNA aptamer as a therapeutic agent for synucleinopathies

Abstract The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodege...

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Autors principals:	Kazuma Murakami, Thi Hong Van Nguyen, Leo Tsuda, Esha Chawla, Yangxia Wang, Yiran Chen, Nadia Stefanova, Chioko Nagao, Kenji Mizuguchi, Shouvik Manna, Samir K. Maji, Hidehito Tochio, Gal Bitan
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-07-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-75209-z
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