Endonuclease G restores lipid homeostasis in spontaneously hypertensive rats: implications for mitochondrial function

BackgroundThe mitochondrial endonuclease G (Endog) is best known for its roles in apoptosis and mitochondrial DNA maintenance, but accumulating evidence suggests broader metabolic functions. The spontaneously hypertensive rat (SHR) carries a natural loss-of-function mutation in Endog associated with...

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Autori principali:	Petr Mlejnek, Miroslava Šimáková, Jan Šilhavý, František Liška, Tomáš Mráček, Josef Houštěk, Irena Marková, Martina Hüttl, Hana Malínská, Michal Pravenec
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Physiology
Soggetti:	endonuclease G (Endog) gene insulin resistance lipid and glucose metabolism spontaneously hypertensive rat (SHR) transgenic
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1835167/full
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