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Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A

The incorporation of bromine, iodine or fluorine into the tricyclic core structure of thiaplakortone A (<b>1</b>), a potent antimalarial marine natural product, is reported. Although yields were low, it was possible to synthesise a small nine-membered library using the previously synthesised Boc-pro...

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Autores principales: Folake A. Egbewande, Brett D. Schwartz, Sandra Duffy, Vicky M. Avery, Rohan A. Davis
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2023-05-01
Colección:Marine Drugs
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Acceso en línea:https://www.mdpi.com/1660-3397/21/5/317
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