Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A

The incorporation of bromine, iodine or fluorine into the tricyclic core structure of thiaplakortone A (<b>1</b>), a potent antimalarial marine natural product, is reported. Although yields were low, it was possible to synthesise a small nine-membered library using the previously synthesised Boc-pro...

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Huvudupphov:	Folake A. Egbewande, Brett D. Schwartz, Sandra Duffy, Vicky M. Avery, Rohan A. Davis
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2023-05-01
Serie:	Marine Drugs
Ämnen:	halogenation late-stage functionalization <i>N</i>-bromosuccinimide <i>N</i>-iodosuccinimide sulfinate Diversinate™
Länkar:	https://www.mdpi.com/1660-3397/21/5/317
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