Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease

The goal of this study was to determine if transplantation of enteric neural stem cells (ENSCs) can rescue the enteric nervous system, restore gut motility, reduce colonic inflammation, and improve survival in the Ednrb-KO mouse model of Hirschsprung disease (HSCR). ENSCs were isolated from mouse in...

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Detalhes bibliográficos

Principais autores:	Ahmed A. Rahman, Takahiro Ohkura, Sukhada Bhave, Weikang Pan, Kensuke Ohishi, Leah Ott, Christopher Han, Abigail Leavitt, Rhian Stavely, Alan J. Burns, Allan M. Goldstein, Ryo Hotta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2024-09-01
coleção:	JCI Insight
Assuntos:	Cell biology Gastroenterology
Acesso em linha:	https://doi.org/10.1172/jci.insight.179755
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