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ZAB260: A novel and potent antibacterial agent targeting DNA gyrase

DNA gyrase and topoisomerase IV are well-established targets for antibiotics. These enzymes play crucial roles in managing the topology of DNA, which is essential for bacterial survival. ZAB260, an inhibitor of bacterial DNA gyrase, is a dihydroquinoline carbonitrile-based antibacterial agent, which...

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Autori principali: Sanjay Kumar, Bhaumin Patel, Jinal Trivedi, Purvi Vyas, Vishwanath Pawar, Poonam Giri, S. Sachchidanand, Kasinath Viswanathan, Rajiv Sharma, Mukul Jain, Pravin Iyer, Jigar Desai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-06-01
Serie:The Microbe
Soggetti:
ZAB260
Minimum inhibitory concentration
Post antibiotic effect
Lung infection
Accesso online:http://www.sciencedirect.com/science/article/pii/S2950194625001116
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