Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion

Abstract Background The Salmonella stress response regulator CpxR controls the AcrEF drug efflux pump, which is crucial for key virulence traits such as invasiveness and disruption of the host paracellular pathway. Understanding the role of acrEF and its regulation by CpxR can provide new insights i...

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Autores principales:	Perumalraja Kirthika, Amal Senevirathne, Vijayakumar Jawalagatti, Suyeon Park, Jun Kwon, John Hwa Lee
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-10-01
Colección:	Biology Direct
Materias:	Salmonella typhimurium CpxR AcrEF efflux pump Virulence regulation Tight junction Epithelial invasion
Acceso en línea:	https://doi.org/10.1186/s13062-025-00695-y
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