J2R/F4L deleted oncolytic vaccinia virus synergizes with tumor specific killer (ELANE) promotes antitumor immunity with superior safety

BackgroundOncolytic virotherapy (OVT) represents a promising approach for cancer treatment, employing oncolytic viruses (OVs) that selectively infect and lyse tumor cells while promoting an antitumor immune microenvironment. Vaccinia virus (VACV) serves as an attractive oncolytic vector due to its f...

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Hlavní autoři:	Yu Huang, Liming Wang, Shan Mei, Fei Zhao, Lingwa Wang, Yu Xie, Zhao Gao, Jiaxun Wang, Ziyue Kong, Yurong He, Yueyue Shi, Wenkai Guo, Bin Ai, Jugao Fang, Fengwen Xu, Fei Guo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-07-01
Edice:	Frontiers in Immunology
Témata:	human neutrophil elastase immunogenic cell death oncolytic virus tumor microenvironment vaccinia virus
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1861346/full
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