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J2R/F4L deleted oncolytic vaccinia virus synergizes with tumor specific killer (ELANE) promotes antitumor immunity with superior safety

BackgroundOncolytic virotherapy (OVT) represents a promising approach for cancer treatment, employing oncolytic viruses (OVs) that selectively infect and lyse tumor cells while promoting an antitumor immune microenvironment. Vaccinia virus (VACV) serves as an attractive oncolytic vector due to its f...

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Автори: Yu Huang, Liming Wang, Shan Mei, Fei Zhao, Lingwa Wang, Yu Xie, Zhao Gao, Jiaxun Wang, Ziyue Kong, Yurong He, Yueyue Shi, Wenkai Guo, Bin Ai, Jugao Fang, Fengwen Xu, Fei Guo
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2026-07-01
Серія:Frontiers in Immunology
Предмети:
human neutrophil elastase
immunogenic cell death
oncolytic virus
tumor microenvironment
vaccinia virus
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1861346/full
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