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Complete response in a lung adenocarcinoma with pleural metastases initially treated with gefitinib and switched to osimertinib after cerebral oligo-progression with unknown T790M mutation: a case report and review of literature

Abstract Background First- and second-generation anti-epithelial growth factor receptor tyrosine kinase inhibitors have shown great efficacy in the treatment of advanced adenocarcinoma with epithelial growth factor receptor mutations, but this efficacy is limited by certain resistance mechanisms, in...

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Principais autores: Mariem Hachlaf, Sihame Lkhoyaali, Wydad Nadir, Hajar Lemsyeh, Brahim El Ghissassi, Hind Mrabti, Saber Boutayeb, Hassan Errihani
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:Journal of Medical Case Reports
Assuntos:
NSCLC
EGFR mutation
Gefitinib
T790M mutation
Osimertinib
Cerebral oligo-progression
Acesso em linha:https://doi.org/10.1186/s13256-024-04706-w
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