Spatial and temporal intratumoral heterogeneity in breast cancer: a systematic and conceptual review of single-cell and spatial omics studies

Abstract Background Spatial and temporal intratumoral heterogeneity (ITH) remains a major challenge in the diagnosis, prognosis, and treatment of breast cancer. Recent advances in single-cell and spatial omics technologies have enabled unprecedented resolution of subclonal architectures, evolutionar...

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Auteurs principaux:	Imad Barjij, Oumaima Lamsyah, Sanae Kdadri, Sihame Lkhoyaali, Salma Najem, Sarah Naciri, Hanane Inrhaouen, Ibrahim Elghissassi, Saber Boutayeb, Hind Mrabti, Hassan Errihani
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2026-04-01
Collection:	BMC Cancer
Sujets:	Breast cancer Intratumoral heterogeneity Single-cell RNA sequencing (scRNA-seq) Spatial transcriptomics Tumor microenvironment Clonal evolution
Accès en ligne:	https://doi.org/10.1186/s12885-026-15928-0
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