15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation

Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phos...

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Detalhes bibliográficos

Principais autores:	Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2022-01-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Metabolism Pulmonology
Acesso em linha:	https://doi.org/10.1172/JCI151685
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