15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation

Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phos...

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Autors principals:	Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 2022-01-01
Col·lecció:	The Journal of Clinical Investigation
Matèries:	Metabolism Pulmonology
Accés en línia:	https://doi.org/10.1172/JCI151685
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