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Dissociation of GLP-1 and insulin association with food processing in the brain: GLP-1 sensitivity despite insulin resistance in obese humans

Objective: Glucagon-like peptide-1 (GLP-1) is released into the bloodstream after food intake. In addition to stimulating insulin release, it causes satiety and contributes to the termination of food intake. In this study, we investigated whether endogenous GLP-1 affects food-related brain activity...

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Main Authors: Martin Heni, Stephanie Kullmann, Baptist Gallwitz, Hans-Ulrich Häring, Hubert Preissl, Andreas Fritsche
Format: Artigo
Language:Inglês
Published: Elsevier 2015-12-01
Series:Molecular Metabolism
Subjects:
Glucagon-like peptide-1
Incretin
Brain
fMRI
Orbitofrontal cortex
Brain insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001775
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