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Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer

Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology. Despite intensive efforts to discover therapeutic strategies to re-transform cancer cells into normal cells, no effective appr...

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Principais autores: Yonghyo Kim, Myoung-Hee Kang, Geon-Woo Kim, Yong-Hee Cho
Format: Artigo
Sprog:Inglês
Udgivet: The Organoid Society 2023-03-01
Serier:Organoid
Fag:
colorectal neoplasms
tumor organoids
wnt/β-catenin pathway
ras signaling pathway
destabilization
bmp4
normal-appearing structure
anti-cancer effect
kya1797k
Online adgang:http://j-organoid.org/upload/pdf/organoid-2023-3-e4.pdf
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