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Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells

Summary: Endosomal Toll-like receptors (eTLRs) are essential for the sensing of non-self through RNA and DNA detection. Here, using spatiotemporal analysis of vesicular dynamics, super-resolution microscopy studies, and functional assays, we show that endomembrane defects associated with the deficie...

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Main Authors: Juan Yu, Elsa Meneses-Salas, Jennifer L. Johnson, Susanna Manenti, Mouad Ait Kbaich, Danni Chen, Kasra Askari, Jing He, Aparna Shukla, Binchu Shaji, Rosana Gonzalez-Quintial, Ben A. Croker, Jinzhong Zhang, Hal Hoffman, William B. Kiosses, Catherine Hedrick, Kersi Pestonjamasp, Nathan Wineinger, Roberto Baccala, Sergio D. Catz
Format: Artigo
Language:Inglês
Published: Elsevier 2024-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724009379
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