HexSDF Is Required for Synthesis of a Novel Glycolipid That Mediates Daptomycin and Bacitracin Resistance in C. difficile

ABSTRACT Clostridioides difficile is a Gram-positive opportunistic pathogen responsible for 250,000 hospital-associated infections, 12,000 hospital-associated deaths, and $1 billion in medical costs in the United States each year. There has been recent interest in using a daptomycin analog, surotomy...

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Principais autores:	Anthony G. Pannullo, Ziqiang Guan, Howard Goldfine, Craig D. Ellermeier
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2023-04-01
Colecção:	mBio
Assuntos:	two-component regulatory system cell envelope signal transduction gene expression glycolipid synthesis membrane biogenesis
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.03397-22
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