A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies

The human immune system uses antibodies to neutralize foreign antigens. They are composed of heavy and light chains, both with constant and variable regions. The variable region has six hypervariable loops, also known as complementary-determining regions (CDRs) that determine antibody diversity and...

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Bibliografiske detaljer

Principais autores:	Oscar Mejias-Gomez, Andreas V. Madsen, Kerstin Skovgaard, Lasse E. Pedersen, J. Preben Morth, Timothy P. Jenkins, Peter Kristensen, Steffen Goletz
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2023-12-01
Serier:	mAbs
Fag:	Amino acid diversity antibodies/immunoglobulins antibody sequencing antibody therapeutics development antibody-antigen complexes Complementary-Determining Regions (CDRs)
Online adgang:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2268255
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