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Investigation on environmental factors contributing to bispecific antibody stability and the reversal of self-associated aggregates

Abstract Bispecific antibodies (bsAbs) hold promises for enhanced therapeutic potential surpassing that of their parental monoclonal antibodies. However, bsAbs pose great challenges in their manufacturing, and one of the common reasons is their susceptibility to aggregation. Building on previous stu...

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Autori principali: Nattha Ingavat, Nuruljannah Dzulkiflie, Jia Min Liew, Xinhui Wang, Eunice Leong, Han Ping Loh, Say Kong Ng, Yuansheng Yang, Wei Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: SpringerOpen 2024-08-01
Serie:Bioresources and Bioprocessing
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Accesso online:https://doi.org/10.1186/s40643-024-00796-y
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