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Design, optimization of Niosomal gel capability for solubility and bioavailability enhancement of Kynurenic acid after intranasal administration: In Vitro and In Vivo Evaluation

Abstract Background Kynurenic acid (KNA) could be useful in treating neurological diseases; nevertheless, the fact that it couldn’t penetrate the blood-brain barrier (BBB) limits its neuroprotective efficacy. Research is being conducted on drug delivery devices to transport KNA to the brain. Objecti...

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Autori principali: Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Shaik Abdul Rahaman, Mounika Bodige, Vijaya Kishore Kanakaraju, Marati Kavitha, Darla Srinivasarao, Achor Mohammed, Narayana Goruntla, Tadele Mekuriya Yadesa
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-12-01
Serie:BMC Biotechnology
Soggetti:
Kynurenic acid
Blood brain barrier
Neurological
Niosomes
Pharmacokinetics
Bioavailability
Accesso online:https://doi.org/10.1186/s12896-025-01069-y
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