Comprehensive Identification and Mechanistic Evaluation of Novel DHODH Inhibitors as Potent Broad-Spectrum Antiviral Agents

<b>Background/Objectives</b>: This study identifies novel dihydroorotate dehydrogenase (DHODH) inhibitors exhibiting potent broad-spectrum antiviral agents, particularly against influenza A virus (A/PR/8/34(H1N1)) and SARS-CoV-2. <b>Methods</b>: Structure-based virtual screening of 1.6 million compo...

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Autori principali:	Chao Zhang, Shiyang Sun, Huiru Xie, Yongzhao Ding, Chun Hu, Jialin Guo, Junhai Xiao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-09-01
Serie:	Pharmaceuticals
Soggetti:	dihydroorotate dehydrogenase broad-spectrum antiviral agents MD simulation influenza virus SARS-CoV-2
Accesso online:	https://www.mdpi.com/1424-8247/18/9/1416
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