Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by profound neuronal and cognitive decline, with increasing evidence implicating astrocyte dysfunction in disease pathology. While traditional therapeutic approaches have primarily targeted neurons, the crucial role o...

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Podrobná bibliografie

Hlavní autoři:	Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-08-01
Edice:	Brain, Behavior, & Immunity - Health
Témata:	Alzheimer's disease Familial Alzheimer's disease Astrocyte dysfunction Multiomic analysis Transcriptomics Kinomics
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666354625001024
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