CYP3A genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study

Background: Taxane-induced peripheral neuropathy (TIPN) is an important cause of premature treatment cessation and dose-limitation in cancer therapy. It also reduces quality of life and survivorship in affected patients. Genetic polymorphisms in the CYP3A family have been investigated but the findin...

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Hauptverfasser:	Laurence McEvoy, Joanne Cliff, Daniel F Carr, Andrea Jorgensen, Rosemary Lord, Munir Pirmohamed
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-07-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	chemotherapy cytochrome P450 peripheral neuropathy personalised medicine pharmacogenetics
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1178421/full
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