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CYP3A genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study

Background: Taxane-induced peripheral neuropathy (TIPN) is an important cause of premature treatment cessation and dose-limitation in cancer therapy. It also reduces quality of life and survivorship in affected patients. Genetic polymorphisms in the CYP3A family have been investigated but the findin...

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Autors principals: Laurence McEvoy, Joanne Cliff, Daniel F Carr, Andrea Jorgensen, Rosemary Lord, Munir Pirmohamed
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-07-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2023.1178421/full
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