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Detection of circulating hybrid cells and circulating tumor cells in cerebrospinal fluid for leptomeningeal metastasis diagnosis and therapeutic prediction

PurposeLeptomeningeal metastasis (LM) represents a serious complication of advanced malignancies with poor prognosis. Conventional diagnostic approaches, such as MRI and cerebrospinal fluid (CSF) cytology lack sufficient sensitivity—particularly in early-stage disease or when imaging modalities are...

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Principais autores: Yanting Liu, Jiaxin Liang, Min Zhang, Nianhua Cao, Jie Xue, Xiaodi Zhang, YongXu Jia, Zhiwei Chang, Guodong Zhang, Yan Li, Hongyan Hui, Ruijuan Fan, Kelei Zhao, Zongbin Liu, Guifang Zhang, Ping Lu, Yinghua Ji
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
leptomeningeal metastasis
diagnosis
cerebrospinal fluid
circulating tumor cells
circulating hybrid cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2025.1716168/full
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