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Induction and characterization of neoplastic bladder tumors in a transgenic porcine model

Background Large animal models of bladder cancer are lacking. Objective This study aimed to develop and characterize a transgenic porcine model of bladder cancer (BC) using Oncopigs expressing Cre-inducible KRAS G12D and TP53 R167H mutations. Methods Eleven female Oncopigs underwent tumor induction...

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Principais autores: Andreas Aulitzky, Viranda H Jayalath, Abraham Meyerson, Sanaz Firouzi, Daniel V Rodriguez, Rebecca Dubrovsky, Laura Alvim, Caoimhe Ryan, Rand Wilcox Vanden Berg, Christopher Cheleuitte-Nieves, Alexandre Doudt, Lennert Eismann, Natasha Kudinova, Kwanghee Kim, Hikmat Al-Ahmadie, Sebastien Monette, Shahrokh F Shariat, Jonathan A Coleman
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publishing 2026-09-01
coleção:Bladder Cancer
Acesso em linha:https://doi.org/10.1177/23523735261439691
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