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Implementation and implications for polygenic risk scores in healthcare

Abstract Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWASs), are able to stratify individuals based on their genetic risk of developing va...

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Principais autores: John L. Slunecka, Matthijs D. van der Zee, Jeffrey J. Beck, Brandon N. Johnson, Casey T. Finnicum, René Pool, Jouke-Jan Hottenga, Eco J. C. de Geus, Erik A. Ehli
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2021-07-01
סדרה:Human Genomics
נושאים:
Polygenic risk score
PRS
Clinical genetics
Genetic risk
Risk stratification
Public health
גישה מקוונת:https://doi.org/10.1186/s40246-021-00339-y
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