Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model

Abstract Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies cellular aging and drives poorly understood disease processes. Here, we studied how AGEs contribute to development of early onset Parkinson’s Disease (PD) caused by loss-of-function of DJ1, a protein deglycase...

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Principais autores:	Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen Whitney, Ricardo Reyes, Lily Sarrafha, Ki Hong Nam, Soha Sohail, Drew R. Jones, John F. Crary, Alban Ordureau, Joel Blanchard, Tim Ahfeldt
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-01-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-024-44732-2
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