TBK1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Mechanistic Insights into Impaired Autophagy and Proteostatic Failure

Mutations in the TANK-binding kinase 1 (TBK1) gene represent a significant genetic link across the Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) spectrum. As a multifunctional serine/threonine kinase, TBK1 serves as a central orchestrator of the autophagy–lysosome pathway, re...

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Bibliographic Details

Main Authors:	Francesca Manganelli, Camilla Perfetto, Olga Carletta, Valeria Gerbino
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2026-03-01
Series:	Cells
Subjects:	Amyotrophic Lateral Sclerosis (ALS) frontotemporal dementia (FTD) autophagy TANK-binding kinase 1 (TBK1)
Online Access:	https://www.mdpi.com/2073-4409/15/5/477
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