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The glycosylation variant at residue 381 of the spike protein contributes to virulence shifts in porcine epidemic diarrhea virus during both natural field transmission and laboratory cell passaging with poor cross-protection

ABSTRACT The virulence and immunogenicity of porcine epidemic diarrhea virus (PEDV) vary during field circulation and cell culture passage (such as when the GI CV777 strain is attenuated through serial passaging). This study revealed that the glycosylation site mutation at position 381 (N381K) of th...

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Autori principali: Zhiwei Li, Zhiqian Ma, Yongqi Li, Xiaojing Zhao, Yonghui Zheng, Yang Li, Yingtong Feng, Xuyang Guo, Zifang Zheng, Lele Xu, Jianwu Zhang, Haixue Zheng, Shuqi Xiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2025-12-01
Serie:Journal of Virology
Soggetti:
porcine epidemic diarrhea virus
glycosylation mutation
viral pathogenesis
cross-protection
spike protein
Accesso online:https://journals.asm.org/doi/10.1128/jvi.01561-25
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