The glycosylation variant at residue 381 of the spike protein contributes to virulence shifts in porcine epidemic diarrhea virus during both natural field transmission and laboratory cell passaging with poor cross-protection

ABSTRACT The virulence and immunogenicity of porcine epidemic diarrhea virus (PEDV) vary during field circulation and cell culture passage (such as when the GI CV777 strain is attenuated through serial passaging). This study revealed that the glycosylation site mutation at position 381 (N381K) of th...

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Autors principals:	Zhiwei Li, Zhiqian Ma, Yongqi Li, Xiaojing Zhao, Yonghui Zheng, Yang Li, Yingtong Feng, Xuyang Guo, Zifang Zheng, Lele Xu, Jianwu Zhang, Haixue Zheng, Shuqi Xiao
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-12-01
Col·lecció:	Journal of Virology
Matèries:	porcine epidemic diarrhea virus glycosylation mutation viral pathogenesis cross-protection spike protein
Accés en línia:	https://journals.asm.org/doi/10.1128/jvi.01561-25
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