Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings

IntroductionLymphocytic variant hypereosinophilic syndrome (L-HES) is a rare subtype of hypereosinophilic syndrome driven by aberrant T-cell clones that promote eosinophilia through interleukin-5 (IL-5) overproduction. While clonal T-cell receptor (TCR) rearrangements are a hallmark, the underlying...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Molly Walkenhorst, Malay K. Basu, Wei Cui, Manish Kumar, Anusha Vallurupalli, Andrea Sitek, Xinyang Zhao, X. Long Zheng, Da Zhang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2025-12-01
Sarja:	Frontiers in Medicine
Aiheet:	lymphocytic variant hypereosinophilic syndrome clonal T-cells eosinophilia STAT3 immune dysregulation transcriptional regulation
Linkit:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1679484/full
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