Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings

IntroductionLymphocytic variant hypereosinophilic syndrome (L-HES) is a rare subtype of hypereosinophilic syndrome driven by aberrant T-cell clones that promote eosinophilia through interleukin-5 (IL-5) overproduction. While clonal T-cell receptor (TCR) rearrangements are a hallmark, the underlying...

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Principais autores:	Molly Walkenhorst, Malay K. Basu, Wei Cui, Manish Kumar, Anusha Vallurupalli, Andrea Sitek, Xinyang Zhao, X. Long Zheng, Da Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
coleção:	Frontiers in Medicine
Assuntos:	lymphocytic variant hypereosinophilic syndrome clonal T-cells eosinophilia STAT3 immune dysregulation transcriptional regulation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1679484/full
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