Computational screening and identification of functional deleterious nsSNPs in the human MAOB gene

Monoamine oxidases (MAOs) are FAD-dependent enzymes responsible for the oxidation of neurotransmitter monoamines. In humans, two isoenzymes exist—MAO-A and MAO-B. Altered or elevated MAO-B levels have been associated with neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. This...

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Principais autores:	Arvind Kumar Yadav, T. P. Krishna Murthy, Prasanna Vijayarengamani, Rohit Shukla, Shishira S. Nair, Ramya Pattabiraman, Sriraksha Prakash, Nimsha Kamala, Durga Prasad, Tiratha Raj Singh
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-01-01
Serija:	In Silico Research in Biomedicine
Teme:	Monoamine oxidases MAO-B Computational tools nsSNPs Neurodegenerative diseases Molecular dynamics simulations
Online dostop:	http://www.sciencedirect.com/science/article/pii/S3050787125001337
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