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Development of an LC–MS/MS method for the quantitation of deoxyglycychloxazol in rat plasma and its application in pharmacokinetic study

Deoxyglycychloxazol (TY501) is a glycyrrhetinic acid derivative which exhibits high anti-inflammatory activity and reduced pseudoaldosteronism compared to glycyrrhetinic acid. In this study, a sensitive and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was established for th...

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Main Authors: Rongshan Li, Ruixue Ran, Quansheng Li, Yurong Huang, Yuan Gu, Duanyun Si
Format: Artigo
Language:Inglês
Published: Elsevier 2016-06-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Deoxyglycychloxazol (TY501)
LC–MS/MS
APCI
Pharmacokinetics
Rat plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177916300090
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