MGMT epimutations and risk of incident cancer of the colon, glioblastoma multiforme, and diffuse large B cell lymphomas

Abstract Background Constitutional BRCA1 epimutations (promoter hypermethylation) are associated with an elevated risk of triple-negative breast cancer and high-grade serous ovarian cancer. While MGMT epimutations are frequent in colon cancer, glioblastoma, and B-cell lymphoma, it remains unknown wh...

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Principais autores:	Oleksii Nikolaienko, Garnet L. Anderson, Rowan T. Chlebowski, Su Yon Jung, Holly R. Harris, Stian Knappskog, Per E. Lønning
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-02-01
Serija:	Clinical Epigenetics
Teme:	Cancer risk MGMT Epimutation Constitutional methylation Colon cancer Glioblastoma
Online dostop:	https://doi.org/10.1186/s13148-025-01835-x
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