Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons

The spontaneous firing of the sinoatrial (SA) node, the physiological pacemaker of the heart, is generated within sinoatrial nodal cells (SANCs) and is regulated by a “coupled-clock” pacemaker system, which integrates a “membrane clock”, the ensemble of ion channel currents, and an intracellular “Ca...

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Manylion Llyfryddiaeth

Prif Awduron:	Tatiana M. Vinogradova, Edward G. Lakatta
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2024-12-01
Cyfres:	Cells
Pynciau:	sinoatrial node cells Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII) sarcoplasmic reticulum local subsarcolemmal Ca<sup>2+</sup> releases (LCRs) phospholamban ryanodine receptors
Mynediad Ar-lein:	https://www.mdpi.com/2073-4409/14/1/3
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