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Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis

Abstract Background Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs or strategies to alleviate this predicament. Celastrol (Cel) is an ext...

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Principais autores: Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang, Gang Liu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Cell Communication and Signaling
Fag:
Celastrol
Antimalarial
Spermidine
Protein synthesis
Online adgang:https://doi.org/10.1186/s12964-023-01409-5
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