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Structural Dissection of the First Events Following Membrane Binding of the Islet Amyloid Polypeptide

The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of IAPP aggregation and being the target of IAPP to...

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Principais autores: Lucie Khemtemourian, Hebah Fatafta, Benoit Davion, Sophie Lecomte, Sabine Castano, Birgit Strodel
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Molecular Biosciences
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fmolb.2022.849979/full
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