Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

DNA double‐strand breaks (DSBs) generated from collisions of DNA replication forks with cisplatin‐induced interstrand crosslinks underpin cisplatin cytotoxicity. Yet, the impact of cell‐cycle‐dependent cisplatin–DNA adduct (CDA) formation on cell cycle progression and interactions with DNA replicati...

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Manylion Llyfryddiaeth

Prif Awduron:	Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2026-07-01
Cyfres:	Molecular Oncology
Pynciau:	cell cycle cisplatin cisplatin‐DNA adducts DNA double‐strand breaks DNA repair radiosensitization
Mynediad Ar-lein:	https://doi.org/10.1002/1878-0261.70240
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!