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Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia

IntroductionTousled-like kinase 2 (TLK2) is a serine/threonine kinase that plays a role in DNA replication, chromatin remodeling, and DNA damage response. TLK2 has been implicated in the pathogenesis of various types of cancer, including breast cancer, glioblastoma, and acute myeloid leukemia (AML)....

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Furkejuvvon:
Váldodahkkit: Hsin-Yun Lin, Sokchea Khou, Evan Lind, Katia G. de Oliveira Rebola, Ariel Dean, Haijiao Zhang, Angelica Tolentino, Hadi Maazi, Alexey Revenko, Anupriya Agarwal
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2026-03-01
Ráidu:Frontiers in Oncology
Fáttát:
AML
antisense oligonucleotide
drug resistance
gilteritinib
Tlk2
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fonc.2026.1659341/full
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