Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia

IntroductionTousled-like kinase 2 (TLK2) is a serine/threonine kinase that plays a role in DNA replication, chromatin remodeling, and DNA damage response. TLK2 has been implicated in the pathogenesis of various types of cancer, including breast cancer, glioblastoma, and acute myeloid leukemia (AML)....

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Autores principales:	Hsin-Yun Lin, Sokchea Khou, Evan Lind, Katia G. de Oliveira Rebola, Ariel Dean, Haijiao Zhang, Angelica Tolentino, Hadi Maazi, Alexey Revenko, Anupriya Agarwal
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Colección:	Frontiers in Oncology
Materias:	AML antisense oligonucleotide drug resistance gilteritinib Tlk2
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1659341/full
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