Trametinib’s Transformative Role in BRAF-Mutated Multisystem Langerhans Cell Histiocytosis: A Case Report

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasm, though rare, of myeloid origin, primarily driven by mutations in the MAPK pathway, most specifically BRAF. It is characterized by having a wide clinical spectrum, including lytic bone lesions, endocrinopathy, and multisystem disease. D...

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Autori principali:	Marlyn Susan George, Abdul Rehman Shahid Khan, Mahin Qudeer Sheikh, Noor ul Sabah, Roma Bai, Yashika Gupta
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The Korean Society of Pediatric Hematology-Oncology 2025-10-01
Serie:	Clinical Pediatric Hematology-Oncology
Soggetti:	langerhans cell histiocytosis braf mutation trametinib multisystem lch case report
Accesso online:	http://www.cpho.or.kr/journal/view.html?doi=10.15264/cpho.2025.32.2.61
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