Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology

Abstract In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their microsatellite-instable (MSI) counterparts. Yet, due to their rarity and the a...

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Hlavní autoři:	Marco Gustav, Nic Gabriel Reitsam, Zunamys I. Carrero, Chiara M. L. Loeffler, Marko van Treeck, Tanwei Yuan, Nicholas P. West, Philip Quirke, Titus J. Brinker, Hermann Brenner, Loëtitia Favre, Bruno Märkl, Albrecht Stenzinger, Alexander Brobeil, Michael Hoffmeister, Julien Calderaro, Anaïs Pujals, Jakob Nikolas Kather
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-05-01
Edice:	npj Precision Oncology
On-line přístup:	https://doi.org/10.1038/s41698-024-00592-z
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!