Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors

BackgroundMicrosatellite instability-high (MSI-high) tumors comprise ~15% of sporadic colorectal cancers (CRC) and are associated with elevated T cell infiltration. However, the universality of this response across T cell subtypes with distinct functions is unknown.MethodsIncluding 1,236 CRC tumors...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Claire E. Thomas, Yasutoshi Takashima, Evertine Wesselink, Tomotaka Ugai, Robert S. Steinfelder, Daniel D. Buchanan, Conghui Qu, Li Hsu, Andressa Dias Costa, Steven Gallinger, Robert C. Grant, Jeroen R. Huyghe, Sushma S. Thomas, Shuji Ogino, Amanda I. Phipps, Jonathan A. Nowak, Ulrike Peters
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2024-12-01
Rangatū:	Frontiers in Immunology
Ngā marau:	microsatellite instability hypermutation DNA mismatch repair T cells epithelial stromal
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505896/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!